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KMID : 1001020180160010038
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Journal of Urologic Oncology
2018 Volume.16 No. 1 p.38 ~ p.41
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Long-Lasting Antiandrogen Withdrawal Syndrome in Castration-Resistant Prostate Cancer: Three Cases With Complete Response
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Kim Sang-Jin
Ryu Jae-Hyun
Kim Yun-Beom
Jung Tae-Young
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Abstract
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This is a case report of 3 patients who had a dramatic and long-term complete response after antiandrogen withdrawal. All 3 patients were diagnosed with advanced or metastatic prostate cancer with a high prostate-specific antigen (PSA) level. For all patients, we started combined androgen blockade as androgen deprivation therapy and the PSA concentration decreased to ＜0.1 ng/mL, but then started to increase. After discontinuation of antiandrogen the PSA concentration decreased again and has remained below the limit of sensitivity for more than 1 year in all 3 patients.
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KEYWORD
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Androgen antagonists, Androgen deprivation therapy, Antiandrogen withdrawal syndrome, Castration resistant prostatic neoplasms, Complete response
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